EUnetHTA JA Methodology Archive (2010 – 2012)

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Methodological guidelines for rapid relative effectiveness assessment (REA) of Pharmaceuticals

1. Clinical endpoints
2. Composite endpoints
3. Surrogate endpoints
4. Safety
5. Health-related quality of life
6. Criteria for the choice of the most appropriate comparator(s)
7. Direct and indirect comparison
8. Internal validity
9. Applicability of evidence in the context of a relative effectiveness assessment

Please note that the updated versions of these Guidelines can be found under JA2 Guidelines here.